In line with our results, Mecp2 knockout mice have been reported to display increased anxiety-like behaviours [101, 104, 106], whereas Stearns et al. [107] found decreased anxiety-like behaviour in mutant Mecp2 mice and Samaco et al. [47] showed that overexpression of Mecp2 also increases anxiety-related behaviours in mice. The gene discussed is MECP2; the disease is Anxiety.