In summary, miR-4319 was downregulated by IFN-γ with upregulation of NLRC5 and promotion on all of the three classic subtypes of human MHC class I, HLA-A, B, and C, in SKBR3 breast cancer cells, suggesting the potential clinical relevance on counteracting cancer evasion from immunosurveillance and benefiting cancer immunotherapy. This evidence concerns the gene IFNG and breast cancer.