In non-small cell lung cancer (NSCLC), GNAS-AS1, a long non-coding RNA, inhibits miR-4319, which promotes macrophages M2 polarization.44 It has been demonstrated that a direct downstream target of miR-4319 is NLRC5 which is an MHC class I transactivator (CITA). The gene discussed is GNAS; the disease is non-small cell lung carcinoma.