After 24-h treatment with IFN-γ, the relative levels of HLA-A, HLA-B and HLA-C mRNA in SKBR3 breast cancer cells were dose dependently increased in all groups treated with different concentrations of IFN-γ compared with the control group with statistical significance (p < .05) (Figures 4a, 5a and 6a). This evidence concerns the gene IFNG and breast cancer.