In summary, miR-4319 was downregulated by IFN-γ with upregulation of NLRC5 and promotion on all of the three classic subtypes of human MHC class I, HLA-A, B, and C, in SKBR3 breast cancer cells, suggesting the potential clinical relevance on counteracting cancer evasion from immunosurveillance and benefiting cancer immunotherapy. Here, NLRC5 is linked to breast carcinoma.