NLRC5 and neoplasm: Recently, MiR-4319 has been found as a tumor suppressor in several human cancers.2 According to prediction by TargetScan (http://www.targetscan.org/), NOD-like receptor (NLR) caspase recruitment domain containing protein 5 (NLRC5) has a complementary binding site for miR-4319, therefore being identified as a potential target of miR-4319.2 NLRC5 is a regulator of MHC class I transcription.3 MHC class I is also known as human leukocyte antigen (HLA) class I in human.