Interferon-γ (IFNγ) is a cytokine with direct cytotoxic effects on tumor cells.20 Our previous study has demonstrated that upregulation of NLRC5 by IFN-γ resulted in increasing MHC class I expression in MHC class I – deficient SKBR3 breast cancer cells.21 However, a crucial remaining unexplored gap is whether IFN-γ can exert its immunomodulatory effects by suppressing miR-4319, thereby facilitating NLRC5-mediated upregulation of MHC class I on cancer cells. This evidence concerns the gene NLRC5 and cancer.