CD8A and cancer: Due to the role of MHC class I in antigen presentation to CD8+ T-lymphocytes, deficient MHC class I molecules have been proved to be one of the most frequent mechanisms among the tumor escape from the host’s immunity described to date.59,60 Recovery of the deficient MHC class I molecules facilitates host immune system to present cancer antigens to cancer killing CD8+ T-lymphocytes for cancer elimination.