In summary, we show that PGRN regulates MERTK and AXL RNA levels in human induced microglia without binding to these receptors, that MERTK is dysregulated in human brain tissue and CSF from GRN-FTD patients, and that concurrent KO of Mertk and Grn in mice rescues Grn-deficient disease-associated microglia phenotype, while concurrent KO of Axl and Grn worsen it. Here, MERTK is linked to frontotemporal dementia.