When considering individual mutations, we observed that the presence of CTNNBI, TP53, KEAP1, and ARID1A mutations was predictive of worse OS on univariable analysis, whilst on multivariable analysis TP53 was retained as a negative prognostic marker, as was the presence of portal vein thrombosis (PVT). This evidence concerns the gene KEAP1 and Portal vein thrombosis.