In the MR analysis of 731 immune cells and 41 cytokines, we found that b-NGF, GROa and SCGFb and 22 immune cells had a causal relationship with CKD, IL4 and 18 immune cells had a causal relationship with eGFR, and IFNg and 22 immune cells were associated with UACR. This evidence concerns the gene IL4 and chronic kidney disease.