The dysregulated genes identified in MB were primarily involved in the regulation of the cell cycle, synaptic vesicle cycle, axon guidance, and miRNAs in cancer, highlighting their crucial role in cellular proliferation, communication, and structural integrity, all of which are vital in the context of MB development and progression and correlate the functions of the selected oncogenes, CORO1C and SV2B. Our in silico analysis revealed distinct prognostic associations for SV2B and CORO1C in MB and GB. This evidence concerns the gene SV2B and cancer.