NFKB1 and cancer: During this process, various factors—such as the excessive production of reactive oxygen and nitrogen species (RONS), the elevated production or activation of crucial arachidonic acid derivatives and cytokines/growth factors (along with their respective signal transduction cascades, e.g., NF-κB), and immune system malfunctions—could all contribute to an elevated risk of cancer and drive the multifaceted development and progression of colorectal cancer6.