Herein, using molecular signatures derived from the cancer genome atlas (TCGA), we identified key hub genes associated with GBM pathogenesis, including CAMK2A, FOXM1, SYN1, CALM1, GRIN2A, NEFL, GABRA1, IL6, ATP2B2, and SNCB60. The gene discussed is ATP2B2; the disease is glioblastoma.