Herein, using molecular signatures derived from the cancer genome atlas (TCGA), we identified key hub genes associated with GBM pathogenesis, including CAMK2A, FOXM1, SYN1, CALM1, GRIN2A, NEFL, GABRA1, IL6, ATP2B2, and SNCB60. Here, SYN1 is linked to glioblastoma.