The findings revealed a U-shaped relationship between ionized calcium and 28-day mortality in patients with sepsis, after adjusting for the following covariates: gender, age, BMI, ethnicity, temperature, respiratory rate, heart rate, MAP, PaO2, PaCO2, WBC, hemoglobin, total bilirubin, albumin, glucose, BUN, creatinine, sodium, potassium, chloride, dialysis, vasopressor, calcium gluconate/calcium chloride, septic shock, COPD, diabetes, hypertension, CHF, MI, CKD, cirrhosis, cancer, PE, stroke, site of infection, APACHE IV score and SOFA score. This evidence concerns the gene ALB and septic shock.