In line with previous studies16, at TP1, DENV2 NS3-specific T-cells in SD patients contained higher percentages of cytokine-producing/CD107a-negative and lower percentages of cytokine-negative/CD107a-positive cells, suggesting a skewing of T-cell responses towards cytokine production in SD and conversely towards cytotoxicity in non-SD patients (Fig. 4f). This evidence concerns the gene LAMP1 and Salla disease.