A recent study including >7400 participants proposed a combination of inflammatory (IL-8, CXCL10/IP-10, sTREM-1, and sCD163) and vascular markers (syndecan-1) as potential biomarkers for severe/moderate dengue, all related to excessive activation of macrophages/myeloid cells, the main targets of DENV infection23. The gene discussed is SDC1; the disease is dengue disease.