Analyses of the frequencies of CD4+/CD8+ T-cells and NK-cells expressing the phenotypic/functional markers show increased frequencies at TP1 in SD patients of CD8+ T-cells and NK-cells expressing the skin homing receptor CLA, and decreased frequencies of GPR56+ (cytotoxic) NK-cells (Fig. 1d, e). The gene discussed is CD8A; the disease is Salla disease.