Further, we found that the amplitude of circadian rhythmicity is reduced by re-introduction of wildtype VHL into 786 O or RCC4 cells (Fig. 1G and Supplenentary Fig. S2B), suggesting that enhanced HIF2α expression may contribute to the unexpectedly robust circadian rhythms observed in ccRCC. This evidence concerns the gene VHL and nonpapillary renal cell carcinoma.