In general, virus-positive tumors had a lower count of nonsynonymous mutations than virus-negative tumors, as reported in individual cancer types116,120,124–127 (Figs. 2A, 2B, Supplementary Data 3 and Supplementary Data 5), including in particular PCNSL125 (Wilcoxon test p = 1.4e-7), cHL (targeted, p = 2.4e-6; WES, p = 0.032; WGS, p = 0.045), PBL120 (p = 0.044), HNSCC126 (p = 6.5e-6) and, as a trend, GC127 (p = 0.086), CC (p = 0.17), and MCC124 (p = 0.072) (Fig. 2A). Here, CXCR1 is linked to cancer.