DDX3X and head and neck squamous cell carcinoma: Similarly, in the TCGA study of HNSCC, DDX3X expression was lower in unmutated male versus female cases (median = 12.58 and 12.99, p < 2.2e-16), and was also lower in cases (3 HPV + ; 2 HPV-) with truncating mutations compared to unmutated cases (median = 10.37 and 12.71, p = 1.5e-4) (Supplementary Fig. S17).