GHRL and cancer: To gain deeper insights into how low-BMI influences the brain secretome in response to elevated plasma ghrelin, we analyzed publicly accessible RNA-seq data from the normal human brain with BMI status (n = 382) from the GTEx (Genotype-Tissue Expression; dbGaP accession number phs000424.v8), in conjunction with the Human Protein Atlas (HPA) database47, and found 7 low BMI-specific secretory genes in the brains of cancer-free subjects with low BMI (Fig. 2F, and Supplementary Table 2; unpaired two-tailed t-test).