Consistent with these findings, we observed a significant correlation between LGR5 expression levels and the expression of β-catenin and related Wnt signaling target genes (MYC, AXIN2, CCND1) in CRC datasets (Supplementary Fig. S3B), whereas LGR6 expression exhibited only a slight correlation with Cyclin D1. Here, LGR6 is linked to colorectal carcinoma.