Among our ACC PDXs, there was considerably lower surface ABCB1 expression in POBNCI_ACC004 (Fig. 4E), which had initial complete responses with ADCT-701 treatment, compared to both 164165 and 592788 (Fig. 3B), which had partial but no complete responses with ADCT-701 treatment. This evidence concerns the gene ABCB1 and adrenal cortex carcinoma.