Lastly, in light of recent studies implicating sexual dimorphism in ACC tumorigenesis58,59, we cannot rule out the possibility that sex may have a role in ADCT-701 efficacy as our experiments were primarily conducted using female patient-derived models; however, DLK1 expression has not been shown to be correlated with sex or hormonal status in ACC17. This evidence concerns the gene DLK1 and adrenal cortex carcinoma.