Strikingly, almost all treatment refractory metastatic adrenal cancers, i.e., ACC and pheochromocytoma/paraganglioma (PCPG), expressed high levels of DLK1 (Fig. 1A), which we also observed among primary adrenal tumors in the TCGA PanCancer dataset11 (Fig. 1B). This evidence concerns the gene DLK1 and adrenal cortex carcinoma.