Furthermore, TCGA analysis also revealed that mRNA levels of KDM4B were significantly lower in various tumors compared to paired normal tissues, including skin cutaneous melanoma (SKCM), ovarian serous cystadenocarcinoma (OV), thyroid carcinoma (THCA), and cervical squamous cell carcinoma (CESC) (Fig. 3E), whereas slightly downregulated in the colorectal cancer (COAD) (Fig. S3B), suggesting that downregulated KDM4B results in cGAS inactivation and immune escape during tumor progression. The gene discussed is CGAS; the disease is cutaneous melanoma.