The findings revealed that co-treatment with IU1-47 notably augmented the secretion of type I interferon (IFN-β1) within the tumor post-RT (Fig. 7B-1); the secretion of downstream effectors, C-X-C motif chemokine 10 (CXCL10) and Ubiquitin-like protein ISG15 (IFN-induced 15 kDa protein, ISG15) (Fig. 7B-2/3), was also similarly elevated. This evidence concerns the gene ISG15 and neoplasm.