USP14 and hepatocellular carcinoma: In our work, we discovered that DUB-mediated deubiquitination potentially confers radioresistance in HCC; therefore, we further applied activity-based profiling using a CRISPR-based DUB screen and identified the targetable DUB USP14 as a significant factor underlying radioresistance, which stabilizes GPX4 in the defense against ferroptosis.