This is now robustly validated across multiple HCC lines (Huh7/SNU449/MHCC97H + 7 additional models in new Fig. S8B–D): Baseline Conditions: Radiation alone fails to reduce GPX4 in any HCC line (Fig. S8B), confirming USP14’s constitutive protective role. The gene discussed is USP14; the disease is hepatocellular carcinoma.