Runt-related transcription factor-1 (RUNX1) levels are increased in mice and patients with cholestasis, and liver-specific Runx1-deficient mice subjected to bile duct ligation as well as mouse and human cell cultures revealed that RUNX1 is involved in bile acid-induced Ccl2 and Cxcl2 expression by hepatocytes through a signaling pathway that remains to be identified [129]. Here, RUNX1 is linked to cholestasis.