CD8A and hepatitis B virus infection: Although hepatocytes can present antigens to T cells through MHC-I [94, 95] and trigger antiviral immune responses after murine hepatitis virus B infection [94, 96, 97], the efficacy of local priming in the liver for virus-specific CD8 + T-cell immunity is low, often leading to dysfunctional CD8 + T cells [98, 99].