BRD4 and digestive system neoplasm: Indeed, in CCl4-mediated chronic liver injury, TNFα in LSECs leads to the interaction of NF-κB with histone acetyltransferase protein 300 (p300) and bromodomain containing 4 (BRD4) to epigenetically upregulate CXCL1 and CCL2, which significantly increases liver inflammation and promotes fibrosis.