In addition, although the expression patterns of key transcription factors indicate that SCLC-A/N is more ASCL1-leaning, clustering analysis (Supplementary Fig. S3A, S3B) revealed heterogeneity within this group: CORL279 clustered closer to the SCLC-N subtype, while the remaining SCLC-A/N aligned more closely with SCLC-A. This evidence concerns the gene ASCL1 and small cell lung carcinoma.