Furthermore, we observed high H3K4me3 and H3K27ac signals around the TSS of NEUROD1 in Lu134A and DMS53 (SCLC-A/N) while not in DMS454 and WA-hT (SCLC-A) (Fig. 2A, right), indicating that both ASCL1 and NEUROD1 are transactivated in SCLC-A/N. This evidence concerns the gene ASCL1 and small cell lung carcinoma.