Our data on CD8 + T cell abundances in tumorous tissues and CCR2/4-dependent tumor control via CD8 + TCA in PCLS cultures as well as other studies concordantly describing homing of CCR4+ CTLs to diseased skin or lung95–97, jointly provide an encouraging therapeutic prospect to improve T cell influx to metastasized lungs by local CCL2 or CCL22 administration. The gene discussed is CCR4; the disease is neoplasm.