Additionally, our findings of upregulated IL-6 and IL-8 genes in the spleen of fish that feed on PB are supported by64 who found that the IL-6 and IL-8 genes, which are critical immune system mediators that facilitate the fish’s response to bacterial infections, were expressed more highly in all groups of European seabass that were fed spirulina. Here, CXCL8 is linked to bacterial infectious disease.