For example, in Parkinson’s disease, the top ten proteins had similar overall importance to the generation of the NN risk score based on similar total absolute SHAP values (PAEP, NEFL, PAFAH1B3, CHRDL2, GFAP, SFRP4, HPGDS, WNT9A, CSDE and IL13RA1); HPGDS and IL13RA1 had an inverse association with disease risk (Fig. 5A). This evidence concerns the gene HPGDS and Parkinson disease.