LINC01518 knockdown in HNSCC cells also results in downregulation of subset of TGF-β target genes such as Slug, GRP78, Serpine1, N-Cadherin, MMP2, Vimentin, ZEB-1, and ZEB-2 and promotes the expression of epithelial marker, E-Cadherin in HNSCC (Fig. 3). This evidence concerns the gene CDH2 and head and neck squamous cell carcinoma.