TYR and melanoma: This study has several limitations: (1) The tyrosinase inhibitory assays were conducted using recombinant human tyrosinase, which may exhibit different activity compared to that in vivo; (2) Only two cell lines, the mouse melanoma B16F10 cells and human immortalized keratinocyte HaCaT cells, were used in this study, and the B16F10 cells are not of human origin; (3) Further experiments are required to explore whether oxyresveratrol affects melanin uptake by HaCaT cells, which is in the research plans.