PPP2CA and Global developmental delay: Case 91: Decreased expression of the PPP2CA gene (Protein Phosphatase 2, Catalytic Subunit, Alpha Isoform associated with AD Houge-Janssens syndrome 3) was identified as an outlier (z-score: −3.51, FC: 0.88, p value: 6.97e−4) in a female with global developmental delay, autism spectrum disorder, epilepsy, atrial septal defects (Fig. 3A).