Consistent with our previous findings23, CFHR5 p.Glu163insAA was substantially more prevalent in unrelated Finns (7/198; AF = 3.54%) relative to all other unrelated 1KG participants (2/1670; AF = 0.12%) (Supplementary Data 6), with the only non-Finnish carriers being two Tuscans from Italy and one African American individual. This evidence concerns the gene CFHR5 and atrial fibrillation.