CFHR5 and age-related macular degeneration: We also replicated our earlier23 finding of a strong association between the low-frequency frameshift variant p.Glu163insAA in CFHR5 (chr1:196994128:C:CAA, rs565457964, CFHR5fs) with protection from AMD (p = 1.1 × 10−68 in univariate analysis) at this locus.