For instance, conditioning on the CFH lead signal rs1410996 reduced the strength of association between the FG lead variant rs61818925 (signal 1.6 in Fig. 1b), a tight proxy for the CFHR1/CFHR3 deletion (r2 = 0.98), and AMD from 6.0 × 10−165 to p = 1.3 × 10−10, and further to p = 0.29 upon jointly conditioning on rs1410996 and CFH p.Tyr402His. The gene discussed is CFHR3; the disease is age-related macular degeneration.