In carriers of AMD protective haplotypes impacting CFH (rs1410996 and CFH p.Tyr402His protective allele carriers, i.e., 1-1-0-0, 1-2-0-0, 2-1-0-0, or 2-2-0-0), these effects showed an opposite effect, as reflected by a decreased inner segment thickness and an increased outer segment thickness (Supplementary Data 20). The gene discussed is CFH; the disease is age-related macular degeneration.