CFH and age-related macular degeneration: Conversely, individuals who carry either CFHR5 p.Gly278Ser or CFHR5fs on top of protective alleles at CFH rs1410996 and p.Tyr402His show the highest protection from AMD (p_cond = 1.5 × 10−18, OR = 0.59 and p_cond = 2.7 × 10−9, beta = 0.52, respectively).