With the wealth of information captured, future research should enable a more granular understanding on how links between distinct haplotypes at GWAS loci are influenced by concomitant genetic variation elsewhere in the genome (such as the ARMS2/HTRA1 locus), environmental contributors (such a smoking, which further increases a genetically elevated risk for AMD in CFH p.Tyr402His carriers43), or aging. The gene discussed is HTRA1; the disease is age-related macular degeneration.