Our results firmly establish that carriers of haplotypes with CFHR5 loss-of-function alleles show a strong, dose-dependent protection from AMD that is additive to that conveyed by common protective alleles in CFH, particularly rs1410996_A and p.402Tyr, which explain the majority of the association signal at the CFH locus3,5. Here, CFHR5 is linked to age-related macular degeneration.