CFHR5 and age-related macular degeneration: Together with our own earlier findings that carriers of the rare CFHR5 p.Glu163insAA (CFHR5fs) variant show a strong protection from AMD23, these earlier studies already indicated that elevated levels of FHR-5 are associated with increased risk for AMD while reduced levels of FHR-5 are associated with a lower risk for AMD, hinting at CFHR5 as a potentially causal contributor to AMD risk at the locus.