Because these are common deletion variants, this provides little support for the hypothesis that variants impacting CFHR1, CFHR3 and CFHR4 coding regions contribute substantially to the strong association between the CFH locus and AMD, while conversely, our results support an eminent role of high-impact variants in CFH and CFHR5 genes. The gene discussed is CFHR4; the disease is age-related macular degeneration.