To further validate whether CFHR5 variants are indeed independently protective for AMD or potentially act in conjunction with yet concealed novel variation at the locus, we next leveraged phased short-read and long-read sequencing data from the expanded 1000 Genomes (1KG) project26,27 and studied the CFH regional architecture at base-level resolution across ethnicities. This evidence concerns the gene CFH and age-related macular degeneration.