For example, CDH3-RBBP5-KRT17, has rather high specificity because RBBP5 almost exclusively regulates the expression of KRT17 rather than other targets; however, its fidelity is not necessarily high, i.e., RBBP5 does not contribute much to the expression of KRT17, indicating that it is not a common transcription factor in cancer cells. The gene discussed is CDH3; the disease is cancer.