To confirm plasmin mediated loss of T-cell membrane FasL in the context of tumor-immune interactions, we subcutaneously grafted uPA/uPAR/plasmin component negative MC38 tumors (Fig. 8h) and plasmin protease component positive ID8OVA tumors on their matched immune-competent hosts C57BL/6 animals (Fig. 8h). The gene discussed is PLG; the disease is neoplasm.