Compared to unmodified micelles, HA functionalization on the R-MFITCHAs significantly enhanced cellular internalization of the micelles by 4T1 tumor cells rather than by M0-BMDMs or naive CD8+ T cells, and far more than by activated CD8+ T cells, validating the tumor cell-targeting capacity of the micellar surface-decorated HA (Fig. 3a and Supplementary Figs. 7 and 8). Here, CD8A is linked to neoplasm.