POT1 and cancer: To identify RNA binding proteins positively associated with telomere length, we used the publicly available Cancer Dependency Map Portal (DepMap Public 23Q4) to determine the linear regression between gene expression (Expression Public 23Q3) and telomere length (TelSeq Telomere Content; CCLE_WGS_Telseq_log2) for 402 RNA binding proteins (RBPDB; http://rbpdb.ccbr.utoronto.ca/), the Cajal body component COIL, and the shelterin complex (TERF2, TERF1, RAP1, ACD, TIN2 and POT1) in 325 cancer cell lines (Supplementary Fig. 1A).