TP53 and neoplasm: We have found high mtDNA copy numbers and abundant somatic SNVs in tumour samples (Fig. 5A; Supplementary Fig. 9A; Supplementary Data 13), such that genes encoded in mtDNA suffer truncating and missense mutations at higher rates than in most other genes, including all known TSGs other than TP53 (Supp Fig. 9B, C).