SEMA3A and type 1 diabetes mellitus: We also identified pathway terms only enriched for new HC substrates, including allograft rejection or type I diabetes mellitus; notably, among these were pathway terms not previously associated with γ-secretase or its substrates, such as glycerophospholipid catabolism and class 3 semaphorin (SEMA3A) related pathway terms (Fig. 9e).