Of particular note, this cluster comprised loci with prioritized lipid metabolism genes, namely, GCKR, TRIB1, FADS2 and previously known HNF1A. Furthermore, it encompassed the locus containing the MLXIPL gene, a transcriptional factor that induces liver glycolysis and lipogenesis, as well as ABO, which is known to be associated with stroke51, metabolic dysfunction-associated steatotic liver disease and levels of lipids52,53. This evidence concerns the gene TRIB1 and liver disorder.