High-risk HPCs gained ATAC-seq peaks enriched in ETS and RUNX motifs, which have been reported to regulate the leukaemic signature in AML patients with CEBPA biallelic mutations (CEBPAN/C)64, whilst enrichment of GATA motifs indicates that the HPCs from high-risk cells are less differentiated than those from low risk, which is consistent with a defect in myeloid differentiation. Here, CEBPA is linked to acute myeloid leukemia.