FRYL and neoplasm: Among the top 10 proteins sequentially ranked according to the fold change value of upregulated phosphorylation, 6 proteins (FRYL, SYNRG, SRRM2, HSP27, RAPH1 and ERBIN) contained the canonical PKA phosphorylation motif RXXS, but only the phosphorylation of HSP27 has been widely reported in tumor biology.