Previous studies demonstrated that the activation of the TLR/MyD88/NF-κB signaling pathway was intimately associated with the development of renal fibrosis, and that renal fibrosis and damage in the LN mouse model could be mitigated by inhibiting the TLR9/MyD88/NF-κB signaling pathway46. The gene discussed is NFKB1; the disease is renal fibrosis.