In contrast to the AR/ESR1 ratio, AR/PGR ratio values ≥ 1.54 were associated with high grades (G2-G3; Odds ratio: 1.353; 95% CI: 1.078–1.698; p = 0.009), larger tumor sizes (T2-T4; Odds ratio: 1.284; 95% CI: 1.015–1.626; p = 0.038), the presence of multiple positive lymph nodes (N2-N3; Odds ratio: 1.8; 95% CI: 1.331–2.436; p < 0.001), and also with HER2 positivity (HER2 +; Odds ratio: 2.084; 95% CI: 1.502–2.890; p < 0.001) (Supplementary Fig. 6 and 7). Here, ESR1 is linked to neoplasm.