It is found that TRIM22 inhibits osteosarcoma (OS) progression by promoting proteasomal degradation of nuclear factor erythroid 2-related factor 2 (NRF2) independent of its canonical regulator Kelch-like ECH-associated protein 1 (KEAP1), thereby activating ROS/AMPK/mTOR/autophagy signaling for autophagic cell death41. The gene discussed is NFE2L2; the disease is osteosarcoma.