Furthermore, in mice treated with 4 g/L STS (STS4), the number of P16INK4A+ nuclei increased in the aortic wall of AAA WT male mice, especially in dedifferentiated VSMC in the neointima media (M) and neointima (NI) regions (Fig. 7d), suggesting that STS also promoted VSMC senescence in vivo. This evidence concerns the gene CDKN2A and triple-A syndrome.