TLR4 and pachyonychia congenita: Among them, CASP9, MTOR, AKT1, TERT, MYC, and NANOG are highly expressed in the normal group, while BRCA1, HSP90 AA1, MET, TNF, CASP8, STAT1, MYD88, CASP3, TLR4, IL1 A, PTGS2, HIF1 A, AREG, MMP9, TGFB1, HMOX1, IL6, NFE2L2, STAT3, NFKB1, PDGFRB, CTNNB1, MMP2, VIM, AXL, PTK2, TJP1, MAPK3, and PPARG are highly expressed in the PC group.