CKD: chronic kidney disease; HF: heart failure; COPD: chronic obstructive pulmonary disease; SOFA: sequential organ failure assessment; GCS: glasgow coma scale; HR: heart rate; MAP: mean arterial pressure; SBP: systolic blood pressure; RR: respiratory rate; WBC: white blood cell count; PT: prothrombin time; PTT: partial thromboplastin time; INR: international normalized ratio; BUN: blood urea nitrogen; ALT: alanine aminotransferase; AST: aminotransferase. The gene discussed is F2; the disease is chronic obstructive pulmonary disease.