Painful cracks and skin fissures of the hands and feet have also been described.54 Other nail changes associated with EGFR inhibitors include mild onycholysis, brittle nails, and slower nail growth.52 Notably, MET inhibitor-associated peripheral edema can make the management of paronychia even more challenging; based on the authors’ experience, patients with edema are at high risk of secondary infections in the setting of a chronic skin source of bacteria at the nail. The gene discussed is MET; the disease is paronychia.