GRIA3 and epilepsy: The GluA3-desensitized interface also harbours the Gly439/Arg439 trafficking checkpoint27, as well as various disease-associated mutations, such as A237T in the vicinity of Gly235, which is associated with epilepsy, as well as T748M and E759K, both on helix J22 (Fig. 3e and Extended Data Fig. 5c).