WD also induces hypothalamus inflammation even before the signs of obesity, such as substantial weight gain and rise in blood glucose levels due to lower GLP-1 production, as elevated GLP-1 protects from the WD-induced hypothalamus inflammation by exerting anti-inflammatory action through GLP-1Rs expressed on astrocytes of the hypothalamus [91,147]. The gene discussed is GCG; the disease is obesity due to melanocortin 4 receptor deficiency.