GCG and Anorexia: For example, lipopolysaccharide (LPS)-induced endotoxaemia increases glucose uptake in the hypothalamus, where it can increase the GLP-1 production from hindbrain GLP-1 neurons that acts on GLP-1Rs expressed on lateral hypothalamus (LH) to induce anorexia as GLP-1 is an anorexigenic peptide [40,48,49].