The increased systemic GLP-1 level further independently correlates and predicts the mortality of critically ill and end-stage renal disease patients admitted in ICUs, serving as an independent predictor of patient survival and providing a superior prognostic measure than circulating C-reactive protein (CRP) as an indicator of systemic inflammation and systemic creatinine level as a marker of kidney disease [47]. Here, GLP1R is linked to chronic kidney disease.