Curiously, HCF-1 is heavily O-GlcNAcylated at over 30 modification sites [26], and loss of O-GlcNAcylation on HCF-1 correlates with binucleation defects in carcinoma cells, a marker of failed cytokinesis or cleavage furrow regression, suggesting distinct roles for HCF-1 cleavage and O-GlcNAcylation in cell cycle progression and mitosis [23]. Here, HCFC1 is linked to carcinoma.