FMR1 and fragile X syndrome: Finally, while spike-distance for ACx units once again increased as a function of frequency separation from CF in both genotypes (GLMM: ***p < 0.0001), the dissimilarity was greater for units from WT compared to Fmr1 KO animals (GLMM: **p = 0.002), indicative of poorer neural discrimination in FXS (Fig 3H).