A correlation between tumour immune microenvironment and VEGF(R-2) has already been described: The activation of VEGF(R-2) is associated with the development of an immunosuppressive microenvironment, by inducing the aggregation of immature dendritic cells, bone marrow-derived suppressor cells and regulatory T cells, and inhibiting T lymphocyte migration [11–13]. This evidence concerns the gene VEGFA and neoplasm.