Therefore, we have identified an immunosuppressive loop involving LAIR1 in the TME, which can be represented as follows: LAIR1 expression on M2-like MΦ↑ → FXIII-A secretion↑ → collagen IV deposition/proliferation↑ → activation of LAIR1+ M2-like MΦ↑ → tumor immunosuppression↑. Here, LAIR1 is linked to neoplasm.