Last, we observed a greater number of tumor-infiltrating L2-8R-70 CAR T cells (CD8+CXCR2+, defined by mouse CD8 and human CXCR2 markers) compared with 8R-70 CAR T cells and the no–CAR T control cells (Figure 5, M and N) (34, 39). Here, CD8A is linked to neoplasm.