We focused here on the hepatic transactivation targets of the mutant GR based on ChIP-Seq/RNA-Seq overlay, and consequently validated Pcsk9 and Bhlhe40 as mediators of the SNP effect on LDLR and SR-B1 levels in the liver, as well as on overall cholesterol levels and atherosclerosis in the hAPOE*2/*2 background. Here, LDLR is linked to atherosclerosis.