APOE and familial hypercholesterolemia: All analyses were adjusted for age, BMI, top 10 principal components, and genotype information for 12 commonly referenced hypercholesterolemia-associated SNPs within PCSK9, CELSR2, APOB, ABCG8, SLC22A1, HFE, MYLIP, ST3GAL4, NYNRIN, LDLR, and APOE genes (23).