PINK1 and idiopathic pulmonary fibrosis: Alveolar epithelial mitochondrial impairments in IPF were first reported with findings of enlarged, dysmorphic mitochondria with impaired electron transport chain complex I and IV activity in AT2 cells from patients with IPF, a phenotype that was associated with decreased expression of the mitophagy regulator PTEN-induced kinase 1 (PINK1) (37).